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solute carrier family 6 (neurotransmitter transporter, SLC6, SLC6A)
Largest of the human solute carrier protein families. Comprises at least 20 members. Originally referred to as neurotransmitter transporter family because it first members encode transporters for the neurotransmitters GABA, noradrenaline, serotonin & dopamine. Orphan members of the family appear to encode transporters for amino acids. [2] SLC6 transporters are ion-coupled (symporters).
Specific
betaine transporter
choline transporter
glutamate/aspartate transporter (excitatory amino acid transporter)
Na+ & Cl- dependent transporter XTRP3 (solute carrier family 6 member 20, neurotransmitter transporter rB21A homolog, SLC6A20, XT3, XTRP3)
Na+ dependent noradrenaline transporter; norepinephrine transporter; NET; solute carrier family 6 member 2 (SLC6A2, NAT1, NET1, SLC6A5)
solute carrier family 6 member 1 (SLC6A1, gamma amino butyric acid [GABA] transporter-1)
solute carrier family 6 member 10 (SLC6A10, Na+ & Cl- dependent creatine transporter 2
solute carrier family 6 member 10 (SLC6A19, Na+ dependent neutral amino acid transporter B0, system B0 neutral amino acid transporter, B0AT1)
solute carrier family 6 member 11 (SLC6A11, Na+/Cl- dependent GABA transporter 3, GABT3, GAT3
solute carrier family 6 member 12; Na+/Cl- betaine/GABA transporter; BGT-1 (SLC6A12)
solute carrier family 6 member 13 (SLC6A13, Na+/Cl- dependent GABA transporter 2
solute carrier family 6 member 14 (SLC6A14, Na+ & Cl- dependent neutral & basic amino acid transporter B0+, amino acid transporter ATB0+)
solute carrier family 6 member 15; orphan Na+ & Cl- dependent neurotransmitter transporter NTT73 (SLC6A15)
solute carrier family 6 member 16 (SLC6A16, orphan Na+ & Cl- dependent neurotransmitter transporter NTT5)
solute carrier family 6 member 17 (SLC6A17, orphan Na+ & Cl- dependent neurotransmitter transporter NTT5)
solute carrier family 6 member 18; Na+ & Cl- dependent transporter XTRP2 (SLC6A18, XTRP2)
solute carrier family 6 member 3 (SLC6A3, dopamine transporter)
solute carrier family 6 member 4 (SLC6A4, serotonin [5HT] transporter)
solute carrier family 6 member 5; Na+- & chloride-dependent glycine transporter 2; GlyT-2; GlyT2 (SLC6A5, GLYT2, NET1)
solute carrier family 6 member 6 (SLC6A6, taurine transporter)
solute carrier family 6 member 7; Na+-dependent proline transporter (SLC6A7, PROT)
solute carrier family 6 member 8 (SLC6A8, Na+ & Cl- dependent creatine transporter 1, creatine transporter 1, CT1
solute carrier family 6 member 9; Na+/Cl- dependent glycine transporter 1; GlyT1 (SLC6A9)
General
glycoprotein
solute carrier family (SLC)
symporter
Properties
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {N-TERMINAL}
exoplasmic loop
LOOP#: 1
exoplasmic loop
LOOP#: 3
exoplasmic loop
LOOP#: 4
exoplasmic loop
LOOP#: 5
exoplasmic loop
LOOP#: 6
exoplasmic loop
MOTIF: N-glycosylation site
cysteine residue {L2.1}
MODIFICATION: cysteine residue {L2.2}
cysteine residue {L2.2}
MODIFICATION: cysteine residue {L2.1}
LOOP#: 2
transmembrane domain {TM1}
transmembrane domain {TM2}
transmembrane domain {TM3}
transmembrane domain {TM4}
transmembrane domain {TM5}
transmembrane domain {TM6}
transmembrane domain {TM7}
transmembrane domain {TM8}
transmembrane domain {TM9}
transmembrane domain {TM10}
transmembrane domain {TM11}
transmembrane domain {TM12}
cytoplasmic loop
LOOP#: 1
cytoplasmic loop
LOOP#: 2
cytoplasmic loop
LOOP#: 3
cytoplasmic loop
LOOP#: 4
cytoplasmic loop
LOOP#: 5
cytoplasmic domain {C-TERMINAL}
References
- Uhl TINS 1992 15:265-8
- Broer S
The SLC6 orphans are forming a family of amino acid
transporters.
Neurochem Int 2006 48:559
PMID: 16540203
- Hahn MK & Blakely RD
The functional impact of SLC6 transporter genetic variation.
Annu Rev Pharmacol Toxicol 2007, 47:401
PMID: 17067279