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solute carrier family 52 member 3; riboflavin transporter 2; hRFT2 (SLC52A3, C20orf54, RFT2)
Function:
- riboflavin transporter
- riboflavin transport is Na+- independent but moderately pH-sensitive
Inhibition:
- activity is strongly inhibited by riboflavin analogs
- lumiflavin
- flavin mononucleotide (FMN)
- flavin adenine dinucleotide (FAD)
- amiloride (to a lesser extent)
Kinetic parameters:
- KM=0.98 uM for riboflavin
Structure: belongs to the riboflavin transporter family
Compartment: cell membrane; multi-pass membrane protein
Alternative splicing: named isoforms=2
Expression:
- expressed in testis
- highly expressed in small intestine & prostate
Pathology:
- defects in SLC52A3 are the cause of
- Brown-Vialetto-Van Laere syndrome type 1
- Fazio-londe disease
Note:
- uncertain whether Met-1 or Met-5 is the initiator
General
glycoprotein
solute carrier family 52 (SLC52, SLC52A)
transmembrane 12 protein
Properties
SIZE: entity length = 469 aa
MW = 51 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {3-23}
transmembrane domain {44-64}
transmembrane domain {72-92}
N-glycosylation site {N94}
transmembrane domain {98-118}
transmembrane domain {138-158}
N-glycosylation site {N168}
transmembrane domain {221-241}
transmembrane domain {293-313}
transmembrane domain {336-356}
transmembrane domain {360-380}
transmembrane domain {382-402}
transmembrane domain {405-425}
transmembrane domain {433-453}
Database Correlations
OMIM correlations
UniProt Q9NQ40
Pfam PF06237
Entrez Gene 113278
Kegg hsa:113278
References
UniProt :accession Q9NQ40