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solute carrier family 44 member 2 (SLC44A2, choline transporter-like protein 2, PSEC0210, CTL2)
Function:
- putative choline transporter
- interacts with COCH
Structure:
- N-glycosylated (putative)
- belongs to the CTL (choline transporter-like) family
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- present in supporting cells of the inner ear (at protein level)
Pathology: possible autoantigen for autoimmune hearing loss
General
choline transporter
glycoprotein
solute carrier family 44 (SLC44, SLC44A)
transmembrane 10 protein
Properties
SIZE: MW = 80 kD
entity length = 706 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-33}
transmembrane domain {34-54}
exoplasmic loop {55-232}
MOTIF: N-glycosylation site {N187}
N-glycosylation site {N200}
transmembrane domain {233-253}
cytoplasmic loop {254-256}
transmembrane domain {257-277}
exoplasmic loop {278-315}
transmembrane domain {316-336}
cytoplasmic loop {337-364}
transmembrane domain {365-385}
exoplasmic loop {386-457}
MOTIF: N-glycosylation site {N417}
transmembrane domain {458-480}
cytoplasmic loop {481-504}
transmembrane domain {505-525}
exoplasmic loop {526-563}
transmembrane domain {564-584}
cytoplasmic loop {585-599}
transmembrane domain {600-620}
exoplasmic loop {621-638}
transmembrane domain {639-659}
cytoplasmic domain {660-706}
Database Correlations
OMIM 606106
UniProt Q8IWA5
Pfam PF04515
Kegg hsa:5715
References
UniProt :accession Q8IWA5