solute carrier family 43 member 1 (large neutral amino acids transporter small subunit 3, L-type amino acid transporter 3, prostate cancer overexpressed gene 1 protein, SLC43A1, LAT3, PB39, POV1)

Function: - Na⁺ independent, high affinity transport of large neutral amino acids - narrower substrate selectivity compared to SLC7A5 & SLC7A8 - mainly transports branched-chain amino acids & phenylalanine Structure: - belongs to the SLC43A transporter (TC 2.A.1.44) family Compartment: membrane (probable) Alternative splicing: named isoforms=2 Expression: - in adults, found in all tissues examined - highest expression in pancreas - in fetus, highest expression in liver & lower levels in kidney, & lung Pathology: - role in development of human prostate cancer - from prostatic intraepithelial neoplasia - to invasive prostate cancer - up-regulated in early prostate cancer development - highest expression in seminomas of testicular germ cell tumors

General

glycoprotein solute carrier family 43 (SLC43, SLC43A) transmembrane 12 protein

Properties

SIZE: MW = 61 kD entity length = 559 aa COMPARTMENT: cellular membrane MOTIF: transmembrane domain {20-40} N-glycosylation site {N57} transmembrane domain {78-98} transmembrane domain {105-124} transmembrane domain {131-151} transmembrane domain {168-188} transmembrane domain {191-211} N-glycosylation site {N212} N-glycosylation site {N229} transmembrane domain {304-324} transmembrane domain {357-377} transmembrane domain {419-439} transmembrane domain {446-466} transmembrane domain {485-505} transmembrane domain {510-530}

Database Correlations

OMIM 603733 UniProt O75387 Kegg hsa:8501

References

UniProt :accession O75387