solute carrier family 39 member 6; Zn+2 transporter ZIP6; Zrt- & Irt-like protein 6; ZIP-6; estrogen-regulated protein LIV-1 (SLC39A6, LIV1, ZIP6)

Function: Zn⁺²-influx transporter Structure: - N-glycosylated - belongs to the ZIP transporter (TC 2.A.5) family Compartment: plasma membrane Alternative splicing: named isoforms=2 Expression: - highly expressed in the breast, prostate, placenta, kidney, pituitary & corpus callosum - weakly expressed in heart & intestine Pathology: - highly expressed in cells derived from an adenocarcinoma of the cervix & lung carcinoma - up-regulated by estrogen in breast cancer cells lines

General

glycoprotein solute carrier family 39 (SLC39, SLC39A) transmembrane 6e protein

Properties

SIZE: MW = 84 kD entity length = 749 aa COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-319} MOTIF: signal sequence {1-28} N-glycosylation site {N67} histidine-rich region {91-128} MOTIF: histidine residue (SEVERAL) N-glycosylation site {N235} N-glycosylation site {N260} N-glycosylation site {N277} transmembrane domain {320-340} cytoplasmic loop {341-349} transmembrane domain {350-370} histidine-rich region {370-385} MOTIF: histidine residue (SEVERAL) exoplasmic loop {371-417} transmembrane domain {418-438} cytoplasmic loop {439-651} MOTIF: lysine-rich region {442-447} MOTIF: lysine residue (SEVERAL) coiled coil {458-480} glutamate-rich region {507-510} MOTIF: glutamate residue (SEVERAL) histidine-rich region {535-572} MOTIF: histidine residue (SEVERAL) transmembrane domain {652-672} exoplasmic loop {673-680} MOTIF: N-glycosylation site {N678} transmembrane domain {681-701} cytoplasmic loop {702-718} transmembrane domain {719-739} exoplasmic domain {740-749}

Database Correlations

OMIM 608731 UniProt Q13433 Pfam PF02535 Kegg hsa:2580

References

UniProt :accession Q13433