Search
solute carrier family 39 member 2 (SLC39A2, Zn+2 transporter ZIP2, Eti-1, 6A1, hZIP2)
Function:
- mediates Zn+2 uptake.
- Zn+2 uptake may be mediated by a Zn+2/HCO3- symport
- functions in the presence of albumin
- may also transport other divalent cations
- role in contact inhibition of epithelial cells (putative)
- Zn+2 uptake is inhibited at pH levels < 7.0
- inhibited by Cu+2, Co+2 & Mn+2, but not Fe+2
Structure: belongs to the ZIP transporter (TC 2.A.5) family
Compartment: cell membrane
Expression:
- expressed only in prostate & uterine epithelial cells
- expression induced in epithelial cells by contact inhibition
Pathology:
- loss of expression may play a role in tumorigenesis
General
glycoprotein
solute carrier family 39 (SLC39, SLC39A)
transmembrane 8e protein
Properties
SIZE: MW = 33 kD
entity length = 309 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-8}
transmembrane domain {9-29}
cytoplasmic loop {30-46}
transmembrane domain {47-67}
exoplasmic loop {68-103}
transmembrane domain {104-124}
cytoplasmic loop {125-164}
transmembrane domain {165-185}
MOTIF: binding site
FOR-BINDING-OF: heavy metal
exoplasmic loop {186-189}
transmembrane domain {190-210}
cytoplasmic loop {211-224}
transmembrane domain {225-245}
exoplasmic loop {246-258}
transmembrane domain {259-279}
cytoplasmic loop {280-288}
transmembrane domain {289-308}
exoplasmic domain {309-309}
Database Correlations
UniProt Q9NP94
Pfam PF02535
Kegg hsa:2998
References
UniProt :accession Q9NP94