solute carrier family 39 member 1 (SLC39A1, Zn+2 transporter ZIP1, hZIP1, Zrt- & Irt-like protein 1, IRT1, Zn+2-iron-regulated transporter-like, ZIRTL, CGI-08, CGI-71)

Function: - mediates Zn⁺² uptake - may function as a major endogenous Zn⁺² uptake transporter in many cells - rapid uptake & accumulation of Zn⁺² in prostate - inhibited by Ni+2, but not Fe⁺² Structure: belongs to the ZIP transporter (TC 2.A.5) family Compartment: - cell membrane - endoplasmic reticulum membrane - vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines Expression: - ubiquitous - expressed in most adult & fetal tissues including epidermis

General

glycoprotein solute carrier family 39 (SLC39, SLC39A) transmembrane 8e protein

Properties

SIZE: MW = 34 kD entity length = 324 aa COMPARTMENT: endoplasmic reticulum MOTIF: exoplasmic domain {1-30} transmembrane domain {31-51} cytoplasmic loop {52-68} transmembrane domain {69-89} exoplasmic loop {90-104} transmembrane domain {105-125} cytoplasmic loop {126-179} transmembrane domain {180-200} MOTIF: binding site SITE: 190-191 FOR-BINDING-OF: heavy metal exoplasmic loop {201-206} transmembrane domain {207-227} cytoplasmic loop {228-237} transmembrane domain {238-258} exoplasmic loop {259-272} transmembrane domain {273-293} cytoplasmic loop {294-303} transmembrane domain {304-323} exoplasmic domain {324-324}

Database Correlations

OMIM 604740 UniProt Q9NY26 Pfam PF02535 Kegg hsa:2717

References

UniProt :accession Q9NY26