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solute carrier family 36 member 1 (SLC36A1, proton-coupled amino acid transporter 1, PAT1, lysosomal amino acid transporter 1, LYAAT1)
Function:
- neutral amino acid/proton symporter
- pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine & proline
- also recognize their D-enantiomers of neutral L-amino acids & some amino acid derivatives such as gamma-aminobutyric acid (GABA)
Structure:
- belongs to the amino acid/polyamine transporter 2 family
Compartment:
- cell membrane, lysosome membrane
Alternative splicing: named isoforms=2
General
glycoprotein
solute carrier family 36 (SLC36, SLC36A)
transmembrane 11e protein
Properties
SIZE: MW = 53 kD
entity length = 476 aa
COMPARTMENT: lysosome
cellular membrane
MOTIF: N-glycosylation site {N31}
N-glycosylation site {N45}
transmembrane domain {52-72}
transmembrane domain {79-99}
N-glycosylation site {N110}
transmembrane domain {142-162}
N-glycosylation site {N174}
N-glycosylation site {N183}
transmembrane domain {191-211}
transmembrane domain {216-236}
transmembrane domain {258-278}
transmembrane domain {290-310}
transmembrane domain {343-363}
transmembrane domain {373-393}
transmembrane domain {398-418}
transmembrane domain {440-460}
N-glycosylation site {N470}
Database Correlations
OMIM 606561
UniProt Q7Z2H8
Pfam PF01490
Kegg hsa:2063
References
UniProt :accession Q7Z2H8