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solute carrier family 35 member D1 (SLC35D1, UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, UDP-GlcA/UDP-GalNAc transporter, UDP-galactose transporter-related protein 7, UGTrel7, KIAA0260)
Function:
- transports both UDP-glucuronic acid (UDP-GlcA) & UDP-N-acetylgalactosamine (UDP-galNAc) from the cytoplasm into the endoplasmic reticulum lumen
- role in glucuronidation &/or chondroitin sulfate biosynthesis (putative)
Structure:
- belongs to the TPT transporter family, SLC35D subfamily
Compartment: endoplasmic reticulum membrane
Expression: ubiquitous
Pathology:
- defects in SLC35D1 are a cause of Schneckenbecken dysplasia
General
glycoprotein
solute carrier family 35 (SLC35, SLC35A, SLC35B, SLC35C, SLC35D, SLC35E)
transmembrane 8 protein
Properties
SIZE: MW = 39 kD
entity length = 355 aa
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {37-59}
transmembrane domain {69-88}
transmembrane domain {158-177}
transmembrane domain {187-205}
transmembrane domain {217-239}
transmembrane domain {254-276}
transmembrane domain {281-303}
transmembrane domain {308-330}
Database Correlations
OMIM correlations
UniProt Q9NTN3
Pfam PF03151
Kegg hsa:2316
References
- UniProt :accession Q9NTN3
- GGDB; Glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/