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solute carrier family 35 member B3; adenosine 3'-phospho 5'-phosphosulfate transporter 2; PAPS transporter 2; 3'-phosphoadenosine 5'-phosphosulfate transporter (SLC35B3, C6orf196, PAPST2, CGI-19)
Function:
- mediates transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi
- compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon
Kinetic parameters: KM=2.2 uM for PAPS
Structure:
- belongs to the nucleotide-sugar transporter family SLC35B subfamily
Compartment: Golgi membrane
Alternative splicing: named isoforms=3
Expression: preferentially & highly expressed in colon
General
glycoprotein
solute carrier family 35 (SLC35, SLC35A, SLC35B, SLC35C, SLC35D, SLC35E)
transmembrane 10e protein
Properties
SIZE: MW = 45 kD
entity length = 401 aa
COMPARTMENT: cellular membrane
MOTIF: N-glycosylation site {N12}
N-glycosylation site {N71}
transmembrane domain {78-98}
transmembrane domain {114-134}
transmembrane domain {147-167}
transmembrane domain {170-190}
transmembrane domain {196-216}
transmembrane domain {223-243}
N-glycosylation site {N254}
transmembrane domain {267-287}
transmembrane domain {298-317}
transmembrane domain {324-346}
transmembrane domain {349-369}
Database Correlations
UniProt Q9H1N7
References
- UniProt :accession Q9H1N7
- GGDB; Glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/