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solute carrier family 34 member 3 (SLC34A3, Na+ dependent phosphate transport protein 2C, Na+/phosphate cotransporter 2C, Na+/Pi cotransporter 2C, NaPi-2c, NPT2C)
Function:
- active transport of phosphate into cells via Na+ cotransport in the renal brush border membrane
- probably mediates 20-30% of the apical influx
Kinetic parameters: KM=79 uM for phosphate
2:1 stoichiometry to Na+/Pi is observed at pH 7.4
Structure: belongs to the SLC34A transporter family
Compartment: membrane
Pathology:
- defects in SLC34A3 are the cause of hereditary hypophosphatemic rickets with hypercalciuria
General
glycoprotein
solute carrier family 34 (SLC34, SLC34A)
transmembrane 8 protein
Properties
SIZE: MW = 64 kD
entity length = 599 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-76}
transmembrane domain {77-97}
exoplasmic loop {98-111}
transmembrane domain {112-132}
cytoplasmic loop {133-188}
transmembrane domain {189-209}
exoplasmic loop {210-322}
MOTIF: N-glycosylation site {N265}
N-glycosylation site {N268}
cysteine residue {C276}
MODIFICATION: cysteine residue {C309}
N-glycosylation site {N286}
N-glycosylation site {N299}
cysteine residue {C309}
MODIFICATION: cysteine residue {C276}
transmembrane domain {323-343}
cytoplasmic loop {344-367}
transmembrane domain {368-388}
exoplasmic loop {389-445}
MOTIF: threonine-rich region {424-427}
MOTIF: threonine residue (SEVERAL)
transmembrane domain {446-466}
cytoplasmic loop {467-485}
transmembrane domain {486-506}
exoplasmic loop {507-510}
transmembrane domain {511-531}
cytoplasmic domain {532-599}
Database Correlations
OMIM correlations
MORBIDMAP 609826
UniProt Q8N130
Pfam PF02690
Kegg hsa:1426
References
UniProt :accession Q8N130