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solute carrier family 34 member 2 (SLC34A2, Na+ dependent phosphate transport protein 2B, Na+/phosphate cotransporter 2B, NaPi-2b, NaPi3b)
Function:
- role in actively transporting phosphate into cells via Na+ cotransport (putative)
- may be the main phosphate transport protein in the intestinal brush border membrane
- role in synthesis of lung alveolar surfactant (putative)
- optimum pH=6.6
Structure: belongs to the SLC34A transporter family
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- highly expressed in lung
- also detected in pancreas, kidney, small intestine, ovary, testis, prostate & mammary gland
- in lung, found in alveolar type II cells but not in bronchiolar epithelium
- down-regulated by EGF
Pathology:
- defects in SLC34A2 are a cause of pulmonary alveolar microlithiasis
General
glycoprotein
solute carrier family 34 (SLC34, SLC34A)
transmembrane 8 protein
Properties
SIZE: MW = 76 kD
entity length = 690 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-100}
transmembrane domain {101-121}
exoplasmic loop {122-135}
transmembrane domain {136-156}
cytoplasmic loop {157-212}
transmembrane domain {213-233}
exoplasmic loop {234-362}
MOTIF: N-glycosylation site {N295}
cysteine residue {C303}
MODIFICATION: cysteine residue {C350}
N-glycosylation site {N308}
N-glycosylation site {N313}
N-glycosylation site {N321}
N-glycosylation site {N340}
cysteine residue {C350}
MODIFICATION: cysteine residue {C303}
transmembrane domain {363-383}
cytoplasmic loop {384-407}
transmembrane domain {408-428}
exoplasmic loop {429-485}
MOTIF: threonine-rich region {464-467}
MOTIF: threonine residue (SEVERAL)
transmembrane domain {486-506}
cytoplasmic loop {507-525}
transmembrane domain {526-546}
exoplasmic loop {547-552}
transmembrane domain {553-573}
cytoplasmic domain {574-689}
MOTIF: cysteine-rich region {612-644}
MOTIF: cysteine residue (SEVERAL)
Database Correlations
OMIM correlations
UniProt O95436
Pfam PF02690
Kegg hsa:1056
References
- UniProt :accession O95436
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC34A2