solute carrier family 2 member 9 (facilitated glucose transporter); glucose transporter type 9; GLUT-9 (SLC2A9, GLUT9)

Function: - transport of urate & fructose - may have a role in urate reabsorption by proximal tubules - also transports glucose at low rate Structure: - belongs to the major facilitator superfamily, sugar transporter (TC 2.A.1.1) family, glucose transporter subfamily Compartment: membrane Alternative splicing: named isoforms=2 Expression: - highest expression in basolateral membranes of proximal renal tubular cells, liver & placenta - also detected in lung, blood leukocytes, heart, skeletal muscle & chondrocytes from articular cartilage - isoform 2 is only detected in the apical membranes of polarized renal tubular cells & placenta - isoform 1 & isoform 2 are detected in kidney membrane (at protein level) Polymorphism: - genetic variations in SLC2A9 influence the variance in serum uric acid concentrations

General

glucose transporter glycoprotein solute carrier family 2 (SLC2, SLC2A)

Properties

SIZE: entity length = 540 aa MW = 59 kD COMPARTMENT: cellular membrane MOTIF: cytoplasmic domain {1-51} transmembrane domain {52-72} exoplasmic loop {73-107} MOTIF: N-glycosylation site {N90} transmembrane domain {108-128} cytoplasmic loop {129-140} transmembrane domain {141-161} exoplasmic loop {162-171} transmembrane domain {172-192} cytoplasmic loop {193-200} transmembrane domain {201-221} exoplasmic loop {222-231} transmembrane domain {232-252} cytoplasmic loop {253-316} transmembrane domain {317-337} exoplasmic loop {338-354} transmembrane domain {355-375} cytoplasmic loop {376-381} transmembrane domain {382-402} exoplasmic loop {403-415} transmembrane domain {416-436} cytoplasmic loop {437-451} transmembrane domain {452-472} exoplasmic loop {473-478} transmembrane domain {479-499} cytoplasmic domain {500-540}

Database Correlations

OMIM correlations UniProt Q9NRM0 Pfam PF00083 Entrez Gene 56606 Kegg hsa:56606