solute carrier family 2 member 8 (facilitated glucose transporter); glucose transporter type 8; GLUT-8; glucose transporter type X1 (SLC2A8, GLUT8, GLUTX1)

Function: - insulin-regulated facilitative glucose transporter - binds cytochalasin B (glucose-inhibitable) - seems to be a dual-specific sugar transporter - inhibitable by fructose - interacts with AP2B1 (putative) Structure: - belongs to the major facilitator superfamily, sugar transporter (TC 2.A.1.1) family, glucose transporter subfamily Compartment: - cell membrane - cytoplasmic vesicle membrane - principally intracellular - may move between intracellular vesicles & plasma membrane - dileucine internalization motif is critical for intracellular sequestration (putative) Expression: - highly expressed in testis - lower amounts present in most other tissues - in testis, down-regulated by estrogen Pathology: - down-regulated in testicular carcinoma

General

glucose transporter glycoprotein solute carrier family 2 (SLC2, SLC2A)

Properties

SIZE: entity length = 477 aa MW = 51 kD COMPARTMENT: cytoplasm MOTIF: cytoplasmic domain {1-25} MOTIF: Dileucine internalization motif {12-13} transmembrane domain {26-46} exoplasmic loop {47-70} transmembrane domain {71-91} cytoplasmic loop {92-96} transmembrane domain {97-117} exoplasmic loop {118-127} transmembrane domain {128-148} cytoplasmic loop {149-156} transmembrane domain {157-177} exoplasmic loop {178-182} transmembrane domain {183-203} cytoplasmic loop {204-256} transmembrane domain {257-277} exoplasmic loop {278-292} transmembrane domain {293-313} cytoplasmic loop {314-319} transmembrane domain {320-340} exoplasmic loop {341-367} MOTIF: N-glycosylation site {N349} transmembrane domain {368-388} cytoplasmic loop {389-404} transmembrane domain {405-425} exoplasmic loop {426-438} transmembrane domain {439-459} cytoplasmic domain {460-477}

Database Correlations

OMIM 605245 UniProt Q9NY64 Pfam PF00083 Entrez Gene 29988 Kegg hsa:29988