solute carrier family 27 member 5 (SLC27A5, long-chain fatty acid transport protein 5, bile acyl-CoA synthetase, BACS, bile acid CoA ligase, BA-CoA ligase, BAL, cholate-CoA ligase, very long-chain acyl-CoA synthetase homolog 2, VLCSH2, VLCS-H2, very long chain acyl-CoA synthetase-related protein, VLACS-related, VLACSR, fatty-acid-coenzyme A ligase, very long-chain 3, fatty acid transport protein 5, FATP-5)

Function: - acyl-CoA synthetase involved in bile acid metabolism - catalyzes 1st step in the conjugation of C24 bile acids (choloneates) to glycine & taurine before excretion into bile canaliculi by activating them to their CoA thioesters - seems to activate secondary bile acids entering the liver from the enterohepatic circulation - in vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy- 5-beta-cholestanate (THCA), the C27 precursor of cholic acid derived from de novo synthesis from cholesterol ATP + cholate + CoA AMP + diphosphate + choloyl-CoA ATP + (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oate + CoA AMP + diphosphate + (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA Structure: - belongs to the ATP-dependent AMP-binding enzyme family Compartment: endoplasmic reticulum membrane Expression: predominantly expressed in liver

General

ligase or synthetase solute carrier family 27 (SLC27, SLC27A) transmembrane 3 protein

Properties

SIZE: MW = 75 kD entity length = 690 aa COMPARTMENT: cellular membrane MOTIF: cytoplasmic domain {1-8} transmembrane domain {9-29} exoplasmic loop {30-30} transmembrane domain {31-51} cytoplasmic domain {52-690} MOTIF: membrane region {56-76}

Database Correlations

OMIM 603314 UniProt Q9Y2P5 Pfam PF00501 Kegg hsa:1099 ENZYME 6.2.1.7

References

UniProt :accession Q9Y2P5