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solute carrier family 22 member 16; carnitine transporter 2; CT2; organic cation/carnitine transporter 6; organic cation transporter OKB1; Fly-like putative transporter 2; Flipt 2 (FLIPT2, SLC22A16, OCT6)
Function:
- high affinity carnitine transporter
- uptake is partially Na+ dependent
- thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa.
- also transports organic cations such as tetraethylammonium (TEA) & doxorubicin
- uptake of TEA is inhibited by various organic cations
- uptake of doxorubicin is Na+-independent
Structure:
- belongs to the major facilitator superfamily, organic cation transporter family
Compartment:
- membrane, cell membrane
- detected in the plasma mebrane of Sertoli cells & in the luminal membrane of epithelial cells in the epididymus
Alternative splicing: named isoforms=3
Expression:
- widely expressed at low levels in adult tissues & fetal brain, lung, liver & kidney
- expressed in testis & epididymus (at protein level)
- expressed at lower levels in bone marrow & fetal liver
- expressed in hematopoietic cells, including CD34(+) leukocytes & leukemia cells
- expressed in endometrium (at protein level) highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase
Pathology:
- abundantly expressed in ovarian cancer clear-cell adenocarcinoma
General
glycoprotein
membrane protein
solute carrier family 22 (SLC22, SLC22A)
Properties
SIZE: entity length = 577 aa
MW = 65 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {23-43}
N-glycosylation site {N57}
N-glycosylation site {N65}
N-glycosylation site {N68}
N-glycosylation site {N108}
transmembrane domain {152-172}
transmembrane domain {183-203}
transmembrane domain {214-234}
transmembrane domain {244-264}
transmembrane domain {268-288}
N-glycosylation site {N345}
N-glycosylation site {N352}
transmembrane domain {359-379}
transmembrane domain {389-409}
transmembrane domain {416-436}
transmembrane domain {441-461}
transmembrane domain {476-496}
transmembrane domain {501-521}
N-glycosylation site {N546}
N-glycosylation site {N558}
Database Correlations
OMIM 608276
UniProt Q86VW1
Pfam PF07690
Kegg hsa:8541
References
UniProt :accession Q86VW1