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solute carrier family 22 member 15 (Fly-like putative transporter 1, Flipt 1, SLC22A15, FLIPT1, UNQ9429/PRO34686)
Function:
- probably transports organic cations (putative)
- appears not to be the agmatine transporter
Structure:
- belongs to the major facilitator superfamily, organic cation transporter family
Compartment: membrane (putative)
Alternative splicing: named isoforms=2
Expression:
- expressed in kidney & brain > skeletal muscle, heart, liver, placenta & white blood cells > lung & spleen > thymus, small intestine & colon
- expressed at low levels at 20-25 weeks of gestation in fetal brain, lung, liver & kidney
Pathology:
- expressed in several intestinal tumor cell lines
General
glycoprotein
membrane protein
solute carrier family 22 (SLC22, SLC22A)
Properties
SIZE: entity length = 547 aa
MW = 61 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {22-42}
N-glycosylation site {N58}
N-glycosylation site {N63}
N-glycosylation site {N80}
N-glycosylation site {N106}
transmembrane domain {111-131}
transmembrane domain {141-161}
transmembrane domain {165-187}
transmembrane domain {201-221}
transmembrane domain {226-246}
transmembrane domain {303-323}
transmembrane domain {338-358}
transmembrane domain {368-388}
transmembrane domain {401-420}
transmembrane domain {433-453}
transmembrane domain {462-482}
glutamate-rich region {529-535}
MOTIF: glutamate residue (SEVERAL)
Database Correlations
OMIM 608275
UniProt Q8IZD6
Pfam PF07690
Kegg hsa:5535
References
UniProt :accession Q8IZD6