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solute carrier family 22 member 11 (organic anion transporter 4, SLC22A11, OAT4)
Function:
- mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate & related compounds
Structure:
- N-glycosylated, contains several complex-type N-glycans
- belongs to the major facilitator superfamily, organic cation transporter family
Compartment: cell membrane
Alternative splicing: named isoforms=2
Expression: detected in placenta & kidney
General
glycoprotein
major facilitator superfamily (MFS)
solute carrier family 22 (SLC22, SLC22A)
transmembrane 12 protein
Properties
SIZE: MW = 60 kD
entity length = 550 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-10}
transmembrane domain {11-31}
exoplasmic loop {32-142}
MOTIF: N-glycosylation site {N39}
N-glycosylation site {N56}
N-glycosylation site {N99}
transmembrane domain {143-163}
cytoplasmic loop {164-174}
transmembrane domain {175-195}
exoplasmic loop {196-200}
transmembrane domain {201-221}
cytoplasmic loop {222-231}
transmembrane domain {232-252}
exoplasmic loop {253-256}
transmembrane domain {257-277}
cytoplasmic loop {278-346}
transmembrane domain {347-367}
exoplasmic loop {368-378}
transmembrane domain {379-399}
cytoplasmic loop {400-402}
transmembrane domain {403-423}
exoplasmic loop {424-430}
transmembrane domain {431-451}
cytoplasmic loop {452-463}
transmembrane domain {464-484}
exoplasmic loop {485-490}
transmembrane domain {491-511}
cytoplasmic domain {512-550}
Database Correlations
OMIM 607097
UniProt Q9NSA0
Pfam PF07690
References
UniProt :accession Q9NSA0