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solute carrier family 21 member 8; solute carrier organic anion transporter family member 1B3; liver-specific organic anion transporter 2; LST-2; organic anion transporter 8; organic anion-transporting polypeptide 8; OATP-8 (SLCO1B3, LST2, OATP1B3, OATP8, SLC21A8)
Function:
- mediates Na+-independent transport of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate & sulfobromophthalein (BSP)
Structure:
- N-glycosylated
- belongs to the organo anion transporter (TC 2.A.60) family
- contains 1 Kazal-like domain
Compartment:
- basal cell membrane
- lateral cell membrane
- detected in basal & lateral plasma membranes of hepatocytes
Expression:
- highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein
- not detected in other tissues
Pathology:
- highly expressed in some cancer cell lines derived from colon, pancreas, liver & gall bladder
General
glycoprotein
organic anion transporting polypeptide (OATP)
solute carrier family 21 (SLC21, SLC21A)
transmembrane 12 protein
Properties
SIZE: entity length = 702 aa
MW = 77 kD
COMPARTMENT: cellular membrane
MOTIF: N-glycosylation site {N8}
transmembrane domain {30-50}
transmembrane domain {65-85}
transmembrane domain {97-117}
N-glycosylation site {N134}
N-glycosylation site {N145}
N-glycosylation site {N151}
transmembrane domain {171-191}
transmembrane domain {207-227}
transmembrane domain {259-279}
N-glycosylation site {N306}
N-glycosylation site {N310}
N-glycosylation site {N317}
N-glycosylation site {N321}
transmembrane domain {336-356}
transmembrane domain {377-397}
transmembrane domain {410-430}
N-glycosylation site {N445}
Kazal-type serine protease inhibitor domain {453-508}
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+0}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+X2}
N-glycosylation site {N503}
FOR-BINDING-OF: serine protease
N-glycosylation site {N516}
transmembrane domain {538-558}
transmembrane domain {575-595}
transmembrane domain {626-646}
Database Correlations
OMIM 605495
UniProt Q9NPD5
PFAM correlations
Entrez Gene 28234
Kegg hsa:28234
References
UniProt :accession Q9NPD5