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solute carrier family 21 member 2; solute carrier organic anion transporter family member 2A1; prostaglandin transporter; PGT (SLCO2A1, SLC21A2)
Function:
- role in prostaglandin function:
a) release of newly synthesized prostaglandins from cells
b) transepithelial transport of prostaglandins
c) clearance of prostaglandins from circulation
- transports PGD2, as well as PGE1, PGE2 & PGF2A
Structure:
- belongs to the organo anion transporter (TC 2.A.60) family
- contains 1 Kazal-like domain
Compartment: membrane
Expression: ubiquitous
General
glycoprotein
solute carrier family 21 (SLC21, SLC21A)
transmembrane 12 protein
Properties
SIZE: entity length = 643 aa
MW = 70 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {27-47}
transmembrane domain {71-91}
transmembrane domain {101-121}
N-glycosylation site {N134}
transmembrane domain {172-192}
transmembrane domain {210-230}
transmembrane domain {258-278}
transmembrane domain {328-348}
transmembrane domain {366-386}
transmembrane domain {400-420}
Kazal-type serine protease inhibitor domain {438-496}
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+0}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+X2}
N-glycosylation site {N478}
N-glycosylation site {N491}
FOR-BINDING-OF: serine protease
transmembrane domain {511-531}
transmembrane domain {551-571}
transmembrane domain {606-626}
Database Correlations
OMIM 601460
UniProt Q92959
PFAM correlations
Entrez Gene 6578
Kegg hsa:6578
References
UniProt :accession Q92959