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solute carrier family 21 member 14; solute carrier organic anion transporter family member 1C1; organic anion transporter F; OATP-F; organic anion transporter polypeptide-related protein 5; OAT-RP-5; OATPRP5; organic anion-transporting polypeptide 14; OATP-14 (SLCO1C1, OATP14, OATPF, SLC21A14)
Function:
- mediates Na+-independent high affinity transport of organic anions such as the thyroid hormones
a) thyroxine (T4)
b) reverse T3 (rT3)
- other potential substrates are transported with much lower efficiency
a) triiodothyronine (T3)
b) 17-beta-glucuronosyl estradiol
c) estrone-3-sulfate
d) sulfobromophthalein (BSP)
Structure:
- belongs to the organo anion transporter (TC 2.A.60) family
- contains 1 Kazal-like domain
Compartment: membrane
Expression:
- highly expressed in brain & in Leydig cells in testis
- detected in many brain regions
- not detected in pons or cerebellum
General
glycoprotein
organic anion transporting polypeptide (OATP)
solute carrier family 21 (SLC21, SLC21A)
transmembrane 10 protein
Properties
SIZE: entity length = 712 aa
MW = 79 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {80-100}
transmembrane domain {111-131}
N-glycosylation site {N146}
transmembrane domain {222-242}
transmembrane domain {270-290}
N-glycosylation site {N309}
transmembrane domain {353-373}
transmembrane domain {393-413}
transmembrane domain {427-447}
Kazal-type serine protease inhibitor domain {470-525}
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+0}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+X2}
N-glycosylation site {N510}
N-glycosylation site {N520}
FOR-BINDING-OF: serine protease
N-glycosylation site {N533}
transmembrane domain {550-570}
transmembrane domain {592-612}
transmembrane domain {643-663}
N-glycosylation site {N692}
Database Correlations
OMIM 613389
UniProt Q9NYB5
PFAM correlations
Entrez Gene 53919
Kegg hsa:53919
References
UniProt :accession Q9NYB5