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solute carrier family 21 member 12; solute carrier organic anion transporter family member 4A1; OATP4A1; colon organic anion transporter; organic anion transporter polypeptide-related protein 1; OATP-RP1; OATPRP1; POAT; organic anion-transporting polypeptide E; OATP-E; Na+-independent organic anion transporter E (SLCO4A1, OATP1, OATPE, SLC21A12)
Function:
- mediates the Na+-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) & rT3, & of estrone-3-sulfate & taurocholate
Structure:
- belongs to the organo anion transporter (TC 2.A.60) family
- contains 1 Kazal-like domain
Compartment: membrane
Alternative splicing: named isoforms=4
Expression:
- widely expressed
- not expressed spleen or leukocytes
General
glycoprotein
organic anion transporting polypeptide (OATP)
phosphoprotein
solute carrier family 21 (SLC21, SLC21A)
transmembrane 12 protein
Properties
SIZE: entity length = 722 aa
MW = 77 kD
COMPARTMENT: cellular membrane
MOTIF: Ser phosphorylation site {S34}
Thr phosphorylation site {T37}
Ser phosphorylation site {S40}
Ser phosphorylation site {S43}
Ser phosphorylation site {S46}
Ser phosphorylation site {S50}
transmembrane domain {104-124}
transmembrane domain {144-164}
transmembrane domain {172-192}
transmembrane domain {229-249}
transmembrane domain {263-283}
transmembrane domain {309-329}
transmembrane domain {372-392}
transmembrane domain {424-444}
transmembrane domain {454-474}
Kazal-type serine protease inhibitor domain {498-555}
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+0}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+X2}
N-glycosylation site {N499}
FOR-BINDING-OF: serine protease
N-glycosylation site {N557}
transmembrane domain {579-599}
transmembrane domain {617-637}
transmembrane domain {667-687}
Database Correlations
OMIM 612436
UniProt Q96BD0
PFAM correlations
Entrez Gene 28231
Kegg hsa:28231
References
UniProt :accession Q96BD0