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solute carrier family 21 member 11; solute carrier organic anion transporter family member 3A1; OATP3A1; organic anion transporter polypeptide-related protein 3; OATP-RP3; OATPRP3; organic anion-transporting polypeptide D; OATP-D; PGE1 transporter; Na+-independent organic anion transporter D (SLCO3A1, OATPD, SLC21A11)

Function: - mediates Na+-independent transport of organic anions such as estrone-3-sulfat - mediates transport of prostaglandins (PGE1 & PGE2, thyroxine (T4), deltorphin II, BQ-123 & vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal Tyr), estrone-3-sulfate, taurocholate, digoxin nor DHEAS Kinetic parameters: - KM=101 nM for PGE1 (isoform 1) - KM=218 nM for PGE1 (isoform 2) - KM=219 nM for PGE2 (isoform 1) - KM=371 nM for PGE2 (isoform 2) Structure: - belongs to the organo anion transporter (TC 2.A.60) family - contains 1 Kazal-like domain Compartment: - membrane - in choroid plexus epithelium - isoform 1 is localized at the basolateral membrane - isoform 2 is localized at the apical membrane, as well as in the subapical intracellular vesicular compartments Alternative splicing: named isoforms=4 Expression: - ubiquitous - highly expressed in spleen & leukocytes - generally, expression of isoform 1 is higher than that of isoform 2 - isoform 2 is particularly abundant in testis & brain - in testis - isoform 1 is - detected in spermatogonia at different stages - absent from Sertoli cells - isoform 2 is - present in both spermatogonia & Sertoli cells (at protein level) - expressed in choroid plexus epithelium - differential expression of both isoforms is observed in various brain regions: - choroid plexus epithelium - isoform 1 - very abundant in the gray matter of frontal cortex - not associated with neuronal cell bodies - not detected in the white matter - isoform 2 - associated with neuronal bodies & axons in both gray matter & white matter of the frontal cortex

General

glycoprotein organic anion transporting polypeptide (OATP) solute carrier family 21 (SLC21, SLC21A) transmembrane 12e protein

Properties

SIZE: entity length = 710 aa MW = 77 kD COMPARTMENT: cellular membrane MOTIF: transmembrane domain {41-61} transmembrane domain {80-100} transmembrane domain {109-129} N-glycosylation site {N153} N-glycosylation site {N169} transmembrane domain {179-199} transmembrane domain {213-233} transmembrane domain {265-285} transmembrane domain {353-373} N-glycosylation site {N381} transmembrane domain {390-410} transmembrane domain {423-443} N-glycosylation site {N457} Kazal-type serine protease inhibitor domain {465-513} MOTIF: cysteine residue {X+0} MODIFICATION: cysteine residue {X+X4} cysteine residue {X+X1} MODIFICATION: cysteine residue {X+X3} cysteine residue {X+X2} MODIFICATION: cysteine residue {X+X5} cysteine residue {X+X3} MODIFICATION: cysteine residue {X+X1} cysteine residue {X+X4} MODIFICATION: cysteine residue {X+0} cysteine residue {X+X5} MODIFICATION: cysteine residue {X+X2} N-glycosylation site {N502} N-glycosylation site {N505} FOR-BINDING-OF: serine protease N-glycosylation site {N519} transmembrane domain {542-562} transmembrane domain {573-593} transmembrane domain {625-645} N-glycosylation site {N686}

Database Correlations

OMIM 612435 UniProt Q9UIG8 PFAM correlations Entrez Gene 28232 Kegg hsa:28232

References

  1. UniProt :accession Q9UIG8
  2. Nezu TI Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. PMID: 10873595
  3. Huber RD et al Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain. Am J Physiol Cell Physiol. 2007 Feb;292(2):C795-806. PMID: 16971491