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solute carrier family 1 member 5; neutral amino acid transporter B(0); ATB(0); Baboon M7 virus receptor; RD114/simian type D retrovirus receptor; Na+-dependent neutral amino acid transporter type 2 (SLC1A5, ASCT2, M7V1, RDR RDRC)
Function:
- broad substrate specificity
- a preference for zwitterionic amino acids
- Na+-dependent
- accepts as substrates all neutral amino acids, including glutamine, asparagine, branched-chain amino acids & aromatic amino acids
- excludes methylated amino acids, anionic amino acids, & cationic amino acids
- cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus & type D simian retroviruses
Structure:
- belongs to the Na+:dicarboxylate (SDF) symporter (TC 2.A.23) family, SLC1A5 subfamily
Compartment:
- membrane
- melanosome (stage 1-4)
Alternative initiation:
- named isoforms=1
- a number of isoforms are produced by alternative initiation
- isoforms start at multiple alternative CUG & GUG codons
Expression:
- expresse in placenta, lung, skeletal muscle, kidney, pancreas, & intestine
General
glycoprotein
solute carrier family 1 (SLC1 SLC1A)
transmembrane 10 protein
Properties
SIZE: entity length = 541 aa
MW = 57 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-52}
MOTIF: acetylation site
SITE: M1
EFFECTOR-BOUND: acetyl
transmembrane domain {53-73}
exoplasmic loop {74-98}
transmembrane domain {99-119}
cytoplasmic loop {120-132}
transmembrane domain {133-153}
exoplasmic loop {154-224}
MOTIF: N-glycosylation site {N163}
N-glycosylation site {N212}
transmembrane domain {225-245}
cytoplasmic loop {246-265}
transmembrane domain {266-286}
exoplasmic loop {287-305}
transmembrane domain {306-326}
cytoplasmic loop {327-335}
transmembrane domain {336-356}
exoplasmic loop {357-376}
transmembrane domain {377-397}
cytoplasmic loop {398-398}
transmembrane domain {399-419}
exoplasmic loop {420-425}
transmembrane domain {426-446}
cytoplasmic domain {446-541}
MOTIF: Ser phosphorylation site {S503}
Thr phosphorylation site {T532}
Ser phosphorylation site {S535}
Database Correlations
OMIM 109190
UniProt Q15758
Pfam PF00375
Entrez Gene 6510
References
UniProt :accession Q15758