Search
solute carrier family 13 member 5 (Na+/citrate cotransporter, NaCT, Na+-coupled citrate transporter, Na+-dependent citrate transporter, SLC13A5, NACT)
Function:
1) high-affinity Na+/citrate cotransporter
2) mediates citrate entry into cells
3) transport process is electrogenic
- trivalent form of citrate rather than divalent form is recognized as a substrate
4) facilitates utilization of circulating citrate for generation of metabolic energy for synthesis of fatty acids & cholesterol
Structure:
- belongs to the SLC13A transporter (TC 2.A.47) family, NADC subfamily
Compartment: membrane
Expression:
- expressed in liver > brain, testis
General
glycoprotein
solute carrier family 13 (SLC13, SLC13A)
transmembrane 12 protein
Properties
SIZE: MW = 63 kD
entity length = 568 aa
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {13-33}
transmembrane domain {53-73}
transmembrane domain {80-100}
transmembrane domain {124-144}
transmembrane domain {215-235}
transmembrane domain {252-272}
transmembrane domain {311-331}
transmembrane domain {353-373}
transmembrane domain {406-426}
transmembrane domain {439-459}
transmembrane domain {487-507}
transmembrane domain {528-548}
N-glycosylation site {N562}
Database Correlations
OMIM 608305
UniProt Q86YT5
Pfam PF00939
References
UniProt :accession Q86YT5