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solute carrier family 13 member 3; Na+/dicarboxylate cotransporter 3; NaDC-3; hNaDC3; Na+-dependent high-affinity dicarboxylate transporter 2 (SLC13A3, NADC3, SDCT2)
Function:
- high-affinity Na+-dicarboxylate cotransporter
- accepts a range of substrates with 4-5 carbon atoms
- stoichiometry is probably 3 Na+ for 1 divalent succinate
Structure:
- belongs to the SLC13A transporter (TC 2.A.47) family NADC subfamily
Compartment:
- cell membrane; multi-pass membrane protein
Alternative splicing: named isoforms=4
Expression:
- expression is highest in kidney
- detected in placenta, brain, liver & pancreas
General
glycoprotein
solute carrier family 13 (SLC13, SLC13A)
transmembrane 11 protein
Properties
SIZE: entity length = 602 aa
MW = 67 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-16}
transmembrane domain {17-37}
exoplasmic loop {38-55}
transmembrane domain {56-76}
cytoplasmic loop {77-82}
transmembrane domain {83-103}
exoplasmic loop {104-137}
transmembrane domain {138-158}
cytoplasmic loop {159-229}
transmembrane domain {230-250}
exoplasmic loop {251-278}
transmembrane domain {279-299}
cytoplasmic loop {300-336}
transmembrane domain {337-357}
exoplasmic loop {358-372}
transmembrane domain {373-393}
cytoplasmic loop {394-461}
MOTIF: membrane region {423-443}
transmembrane domain {462-482}
exoplasmic loop {483-505}
transmembrane domain {506-526}
cytoplasmic loop {527-546}
transmembrane domain {547-567}
exoplasmic domain {568-602}
MOTIF: N-glycosylation site {N586}
N-glycosylation site {N596}
Database Correlations
OMIM 606411
UniProt Q8WWT9
Pfam PF00939
Entrez Gene 64849
References
UniProt :accession Q8WWT9