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solute carrier family 13 member 1; renal Na+/sulfate cotransporter; Na+/sulfate cotransporter; hNaSi-1 (SLC13A1 NAS1 NASI1)
Function:
- Na+/sulfate cotransporter
- mediates sulfate reabsorption in the kidney
- inhibited by thiosulfate, selenate, molybdate, tungstate, citrate & succinate
Structure:
- belongs to the SLC13A transporter (TC 2.A.47) family NADC subfamily
Compartment: membrane
Expression:
- highly expressed in kidney
- not detectable in other tissues tested
General
glycoprotein
solute carrier family 13 (SLC13, SLC13A)
transmembrane 13 protein
Properties
SIZE: entity length = 595 aa
MW = 66 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {13-33}
transmembrane domain {41-61}
transmembrane domain {77-97}
transmembrane domain {108-128}
transmembrane domain {131-151}
N-glycosylation site {N174}
N-glycosylation site {N207}
transmembrane domain {239-259}
transmembrane domain {290-310}
transmembrane domain {348-368}
transmembrane domain {381-401}
transmembrane domain {464-484}
transmembrane domain {491-511}
transmembrane domain {512-532}
transmembrane domain {554-574}
N-glycosylation site {N591}
Database Correlations
OMIM 606193
UniProt Q9BZW2
Pfam PF00939
Entrez Gene 6561
Kegg hsa:6561
References
UniProt :accession Q9BZW2