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solute carrier family 12 member 9 (K+-chloride transporter 9, cation-chloride cotransporter-interacting protein 1, CCC-interacting protein 1, hCIP1, cation-chloride cotransporter 6, hCCC6, WO3.3) (SLC12A9 CCC6 CIP1)
Function:
- may be an inhibitor of SLC12A1
- seems to correspond to a subunit of a multimeric transport system & thus, additional subunits may be required for its function
- interacts with SLC12A1
Structure: belongs to the SLC12A transporter family
Compartment: plasma membrane
Alternative splicing: named isoforms=3
Expression:
- highly expressed in placenta, brain & kidney
- lower expression in lung, liver & heart
General
glycoprotein
membrane protein
solute carrier family 12 (SLC12, SLC12A)
transmembrane 12 protein
Properties
SIZE: entity length = 914 aa
MW = 96 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-36}
transmembrane domain {37-57}
exoplasmic loop {58-72}
transmembrane domain {73-93}
cytoplasmic loop {94-119}
transmembrane domain {120-140}
exoplasmic loop {141-167}
transmembrane domain {168-188}
cytoplasmic loop {189-193}
transmembrane domain {194-214}
exoplasmic loop {215-262}
MOTIF: N-glycosylation site {N228}
N-glycosylation site {N243}
transmembrane domain {263-283}
cytoplasmic loop {284-297}
transmembrane domain {298-318}
exoplasmic loop {319-338}
transmembrane domain {339-359}
cytoplasmic loop {360-390}
transmembrane domain {391-411}
exoplasmic loop {412-416}
transmembrane domain {417-437}
cytoplasmic loop {438-466}
transmembrane domain {467-487}
exoplasmic loop {488-740}
transmembrane domain {741-761}
cytoplasmic domain {762-914}
Database Correlations
UniProt Q9BXP2
Pfam PF00324
Kegg hsa:5699
References
UniProt :accession Q9BXP2