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solute carrier family 12 member 8 (cation-chloride cotransporter 9, SLC12A8, CCC9)
Function:
- cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation
Structure: belongs to the SLC12A transporter family
Compartment: membrane (putative)
Alternative splicing: named isoforms=5
Expression: ubiquitous with very low level in normal skin
Pathology:
- defects in SLC12A8 may be a cause of susceptibility to psoriasis vulgaris
General
glycoprotein
membrane protein
solute carrier family 12 (SLC12, SLC12A)
Properties
SIZE: entity length = 714 aa
MW = 78 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {37-60}
transmembrane domain {72-93}
transmembrane domain {99-116}
transmembrane domain {123-142}
transmembrane domain {154-173}
transmembrane domain {185-205}
N-glycosylation site {N221}
transmembrane domain {233-254}
transmembrane domain {266-289}
transmembrane domain {309-331}
transmembrane domain {360-377}
transmembrane domain {383-403}
transmembrane domain {593-616}
transmembrane domain {622-643}
Database Correlations
OMIM 604316
UniProt A0AV02
Pfam PF00324
References
UniProt :accession A0AV02