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solute carrier family 12 member 7; electroneutral K+-chloride cotransporter 4; K-Cl cotransporter 4 (SLC12A7, KCC4)
Function:
- mediates electroneutral K+-chloride cotransport when activated by cell swelling
- may mediate K+ uptake into Deiters' cells in the cochlea & contribute to K+ recycling in the inner ear
- important for the survival of cochlear outer & inner hair cells & the maintenance of the organ of Corti
- may be required for basolateral Cl- extrusion in the kidney & contribute to renal acidification
- activated by N-ethylmaleimide (NEM)
- inhibited by furosemide, DIDS & bumetanide; inhibition is much stronger in the presence of 50 mM K+
- inhibited by DIOA
- homomultimer & heteromultimer with other K-Cl cotransporters (putative)
Structure:
- belongs to the SLC12A transporter family
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- detected in muscle, brain, lung, heart & kidney
General
glycoprotein
phosphoprotein
solute carrier family 12 (SLC12, SLC12A)
transmembrane 12 protein
Properties
SIZE: entity length = 1083 aa
MW = 119 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-118}
MOTIF: Ser phosphorylation site {S50}
Ser phosphorylation site {S62}
transmembrane domain {119-139}
exoplasmic loop {140-140}
transmembrane domain {141-161}
cytoplasmic loop {162-214}
transmembrane domain {215-235}
exoplasmic loop {236-252}
transmembrane domain {253-273}
cytoplasmic loop {274-275}
transmembrane domain {276-296}
exoplasmic loop {297-415}
MOTIF: N-glycosylation site {N312}
N-glycosylation site {N331}
N-glycosylation site {N344}
N-glycosylation site {N360}
transmembrane domain {416-436}
cytoplasmic loop {437-456}
transmembrane domain {457-477}
exoplasmic loop {478-493}
transmembrane domain {494-514}
cytoplasmic loop {515-553}
transmembrane domain {554-574}
exoplasmic loop {575-577}
transmembrane domain {578-598}
cytoplasmic loop {599-624}
transmembrane domain {625-645}
exoplasmic loop {646-844}
transmembrane domain {845-865}
cytoplasmic domain {866-1083}
MOTIF: Thr phosphorylation site {T926}
Thr phosphorylation site {T980}
Database Correlations
OMIM 604879
UniProt Q9Y666
Pfam PF00324
Entrez Gene 10723
Kegg hsa:10723
References
UniProt :accession Q9Y666