solute carrier family 12 member 5; electroneutral K+-chloride cotransporter 2; K-Cl cotransporter 2; hKCC2; neuronal K-Cl cotransporter (SLC12A5, KCC2, KIAA1176)

Function: - mediates electroneutral K⁺-chloride cotransport in mature neurons - transport occurs under isotonic conditions, but is activated 20-fold by cell swelling - important for Cl^- homeostasis in neurons - homomultimer & heteromultimer with other K-Cl cotransporters - interacts with AP2A1 (putative) Structure: belongs to the SLC12A transporter family Compartment: membrane Alternative splicing: named isoforms=2 Expression: - brain specific, detected in neurons Notes: - inhibited by furosemide & bumetanide

General

glycoprotein solute carrier family 12 (SLC12, SLC12A) transmembrane 12 protein

Properties

SIZE: entity length = 1139 aa MW = 126 kD COMPARTMENT: cellular membrane MOTIF: cytoplasmic domain {1-133} transmembrane domain {134-154} exoplasmic loop {155-155} transmembrane domain {156-176} cytoplasmic loop {177-194} transmembrane domain {195-215} exoplasmic loop {216-216} transmembrane domain {217-237} cytoplasmic loop {238-254} transmembrane domain {255-275} exoplasmic loop {276-277} transmembrane domain {278-298} cytoplasmic loop {299-418} transmembrane domain {419-439} exoplasmic loop {440-458} MOTIF: N-glycosylation site {N442} transmembrane domain {459-479} cytoplasmic loop {480-496} transmembrane domain {497-517} exoplasmic loop {518-569} transmembrane domain {570-590} cytoplasmic loop {591-630} transmembrane domain {631-651} exoplasmic loop {652-847} MOTIF: N-glycosylation site {N833} transmembrane domain {848-868} cytoplasmic domain {869-1139}

Database Correlations

OMIM 606726 UniProt Q9H2X9 Pfam PF00324 Entrez Gene 57468 Kegg hsa:57468