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solute carrier family 12 member 2; bumetanide-sensitive Na+/K+/Cl- cotransporter 1; basolateral Na+/K+/Cl- symporter (SLC12A2, NKCC1)
Function:
- electrically silent transporter system
- mediates Na+ & Cl- reabsorption
- role in regulation of ionic balance & cell volume
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure: belongs to the SLC12A transporter family
Compartment: membrane
Alternative splicing: named isoforms=2
Expression: expressed in many tissues
General
glycoprotein
phosphoprotein
solute carrier family 12 (SLC12, SLC12A)
transmembrane 12 protein
Properties
SIZE: MW = 131 kD
entity length = 1212 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-92}
transmembrane domain {93-113}
MOTIF: alanine residue {93-111} (19)
exoplasmic loop {114-285}
MOTIF: N-glycosylation site {N168}
glycine residue {188-194} (7)
transmembrane domain {286-306}
cytoplasmic loop {307-309}
transmembrane domain {310-330}
exoplasmic loop {331-366}
transmembrane domain {367-387}
cytoplasmic loop {388-410}
transmembrane domain {411-431}
exoplasmic loop {432-435}
transmembrane domain {436-456}
cytoplasmic loop {457-486}
transmembrane domain {487-507}
exoplasmic loop {508-520}
transmembrane domain {521-541}
cytoplasmic loop {542-591}
transmembrane domain {592-612}
exoplasmic loop {613-657}
transmembrane domain {658-678}
cytoplasmic loop {679-678}
transmembrane domain {679-699}
exoplasmic loop {700-724}
transmembrane domain {725-745}
cytoplasmic domain {746-1212}
Database Correlations
OMIM 600840
UniProt P55011
PFAM correlations
Entrez Gene 6558
Kegg hsa:6558
References
UniProt :accession P55011