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solute carrier family 10 member 2; ileal sodium/bile acid cotransporter; ileal Na+/bile acid cotransporter; Na+ dependent ileal bile acid transporter; ileal sodium-dependent bile acid transporter;ileal Na+/taurocholate cotransporting polypeptide (ISBT, ASBT, NTCP2, IBAT)
Function:
- role in Na+ dependent reabsorption of bile acids from the lumen of the small intestine
- role in cholesterol metabolism
Structure:
- monomer & homodimer
- belongs to the Na+:bile acid symporter family
Compartment: membrane
Pathology:
- defects in SLC10A2 are a cause of primary bile acid malabsorption
Pharmacology:
- odevixibat (Bylvay) is FDA-approved to treat pruritus in progressive familial intrahepatic cholestasis
Related
ileum
General
glycoprotein
solute carrier family 10 (SLC10, SLC10A)
transmembrane 8e protein
Properties
SIZE: MW = 38 kD
entity length = 348 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-28}
MOTIF: N-glycosylation site {N10}
transmembrane domain {29-49}
cytoplasmic loop {49-57}
transmembrane domain {58-78}
exoplasmic loop {70-81}
transmembrane domain {82-102}
cytoplasmic loop {103-126}
transmembrane domain {127-147}
exoplasmic loop {148-157}
transmembrane domain {158-178}
cytoplasmic loop {179-195}
transmembrane domain {196-216}
exoplasmic loop {217-224}
transmembrane domain {225-245}
cytoplasmic loop {246-284}
transmembrane domain {285-305}
exoplasmic domain {306-348}
MOTIF: N-glycosylation site {N328}
Database Correlations
OMIM 601295
MORBIDMAP 601295
UniProt Q12908
Pfam PF01758
Kegg hsa:6555
References
UniProt :accession Q12908