solute carrier family 12 member 1 (SLC10A1, Na+/bile acid cotransporter, Na+/taurocholate transport protein, NTCP, GIG29)

Function: - hepatic Na⁺/bile acid uptake exhibits broad substrate specificity & transports various non-bile acid organic compounds as well - dependent on extracellular Na⁺ Structure: belongs to the Na⁺:bile acid symporter family Compartment: membrane

General

glycoprotein solute carrier family 10 (SLC10, SLC10A) transmembrane 8e protein

Properties

SIZE: MW = 38 kD entity length = 349 aa COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-24} MOTIF: N-glycosylation site {N5} N-glycosylation site {N11} transmembrane domain {25-45} cytoplasmic loop {46-59} transmembrane domain {60-80} exoplasmic loop {81-90} transmembrane domain {91-111} cytoplasmic loop {91-119} MOTIF: N-glycosylation site {N117} transmembrane domain {120-140} exoplasmic loop {141-155} transmembrane domain {156-176} cytoplasmic loop {141-155} transmembrane domain {191-211} exoplasmic loop {212-219} transmembrane domain {220-240} cytoplasmic loop {241-282} transmembrane domain {283-303} exoplasmic domain {304-349} MOTIF: N-glycosylation site {N336}

Database Correlations

OMIM 182396 UniProt Q14973 Pfam PF01758 Entrez Gene 6554 Kegg hsa:6554