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soluble Ca+2-activated nucleotidase 1; SCAN-1; Apyrase homolog; MAPK-activating protein PM09; NF-kappa-B-activating protein 107 (CANT1, SHAPY)
Function:
1) Ca+2-dependent nucleotidase, preference for UDP > GDP > UTP > GTP > ADP > ATP
- does not hydrolyze AMP, GMP
Cofactor: Ca+2
Kinetic parameters:
- Optimum pH is 6.8
Structure:
- monomer
- N-glycosylated
- belongs to the apyrase family
Compartment: cell membrane, secreted
Alternative splicing: named isoforms=2
Expression: widely expressed
Pathology:
- defects in CANT1 are the cause of Desbuquois dysplasia
Notes:
- not inhibited by azide
General
Ca+2 binding protein
glycoprotein
membrane protein
nucleotidase
Properties
SIZE: entity length = 401 aa
MW = 45 kD
COMPARTMENT: golgi
endoplasmic reticulum
MOTIF: transmembrane domain {45-62}
N-glycosylation site {N88}
Ca+2-binding site
SITE: 168-168
Ca+2-binding site
SITE: 215-215
Ca+2-binding site
SITE: 284-284
Ca+2-binding site
SITE: 345-345
Ca+2-binding site
SITE: 396-396
Database Correlations
OMIM correlations
UniProt Q8WVQ1
Pfam PF06079
Entrez Gene 124583
KEGG correlations
ENZYME 3.6.1.6
References
UniProt :accession Q8WVQ1