Contents

Search

sodium phosphate (NaH2PO4)

Indications: - hypophosphatemia, phosphate replacement - rickets [9] - bowel preparations (no longer OTC) [8] - constipation [9] Contraindications: - rectal sodium phosphate contraindicated in children < 2 years of age [10] Dosage: 1) IV dosing - give dose based on sodium & phosphate levels 2) see bowel preparation Injection: - 3 mmol of phosphate/mL (15 mL); - MUST BE DILUTED PRIOR TO ADMINISTRATION Adverse effects: - not common (1-10%) - edema, hypotension, hyperphosphatemia*, hypocalcemia*, hypernatremia, calcium phosphate precipitation, nausea/vomiting, diarrhea, acute renal failure [6], chronic renal failure*, seizures# * phosphate toxicity can result in hypocalcemic tetany [3] & chronic renal failure [4,6,7] risk of acute phosphate nephropathy is low [5]

Related

H2PO4- (phosphate) inorganic phosphate; inorganic phosphorous Na+

Specific

Visicol (sodium phosphate)

General

salt metabolic agent (metabolic modifier)

Database Correlations

PUBCHEM cid=24204

References

  1. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  3. Medications Can Cause Seizures Prescriber's Letter 10(3):16 2003 Detail-Document#: 190320 (subscription needed) http://www.prescribersletter.com
  4. Markowitz GS, Stokes MB, Radhakrishnan J, D'Agati VD. Acute phosphate nephropathy following oral sodium phosphate bowel purgative: an underrecognized cause of chronic renal failure. J Am Soc Nephrol. 2005 Nov;16(11):3389-96. Epub 2005 Sep 28. PMID: 16192415
  5. Russman S et al, Risk of impaired renal function after colonoscopy: A cohort study of patients receiving either oral sodium phosphoate or polyethylene glycol. Am J Gastroenterol 2007, 102:2655 PMID: 17970832
  6. Prescriber's Letter 15(5): 2008 Kidney Damage from Sodium Phosphate Bowel Preps Detail-Document#: 240505 (subscription needed) http://www.prescribersletter.com
  7. FDA MedWatch http://www.fda.gov/medwatch/safety/2008/safety08.htm#OSP
  8. Prescriber's Letter 16(1): 2009 Oral Sodium Phosphate Products for Bowel Cleansing: More Safety Concerns Detail-Document#: 250114 (subscription needed) http://www.prescribersletter.com
  9. Deprecated Reference
  10. FDA MedWatch. Jan 8, 2014 Sodium Phosphate Over-the-Counter Products: Drug Safety Communication - Possible Harm From Exceeding Recommended Dose. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm380833.htm

Component-of

alanine/arginine/aspartate/glucose/glutamate/glycine/histidine/isoleucine/leucine/lysine/magnesium chloride/methionine/phenylalanine/potassium chloride/proline/serine/sodium chloride/sodium phosphate/threonine/tryptophan/tyrosine/valine alanine/arginine/aspartate/glutamate/glycine/histidine/isoleucine/leucine/lysine/magnesium chloride/methionine/phenylalanine/potassium chloride/proline/serine/sodium chloride/sodium phosphate/threonine/tryptophan/tyrosine/valine alanine/arginine/glycine/histidine/isoleucine/leucine/lysine/magnesium chloride/methionine/phenylalanine/potassium chloride/proline/serine/sodium chloride/sodium phosphate/threonine/tryptophan/tyrosine/valine betamethasone/sodium phosphate calcium chloride/glucose/magnesium chloride/potassium chloride/sodium bicarbonate/sodium chloride/sodium phosphate calcium chloride/glucose/magnesium sulfate/potassium chloride/sodium bicarbonate/sodium chloride/sodium phosphate Elliotts B Solution (buffered intrathecal electrolyte/dextrose injection) glucose/lactate/magnesium chloride/phosphate/potassium chloride/potassium phosphate/sodium phosphate glucose/lactate/phosphate/potassium chloride/sodium chloride/sodium phosphate glucose/lactate/potassium chloride/potassium phosphate/sodium phosphate glucose/lactate/potassium chloride/sodium chloride/sodium phosphate glucose/magnesium chloride/potassium chloride/potassium phosphate/sodium acetate/sodium chloride/sodium phosphate glucose/magnesium chloride/potassium chloride/potassium phosphate/sodium chloride/sodium lactate/sodium phosphate hyoscyamine/methenamine/methylene blue/phenyl salicylate/salicylate/sodium phosphate hyoscyamine/methenamine/methylene blue/phenyl salicylate/sodium phosphate hyoscyamine/methenamine/methylene blue/salicylate/sodium phosphate hyoscyamine/methenamine/methylene blue/sodium phosphate magnesium chloride/potassium chloride/potassium phosphate/sodium acetate/sodium chloride/sodium gluconate/sodium phosphate magnesium chloride/potassium chloride/potassium phosphate/sodium acetate/sodium chloride/sodium phosphate magnesium sulfate/potassium chloride/potassium phosphate/sodium chloride/sodium phosphate mandelic acid/methenamine/phosphate/sodium phosphate mandelic acid/methenamine/sodium phosphate methenamine/sodium phosphate phosphate/sodium phosphate potassium phosphate/sodium phosphate prednisolone/sodium phosphate/sulfacetamide sodium bicarbonate/sodium chloride/sodium phosphate sodium biphosphate/sodium phosphate sodium fluoride/sodium phosphate