Na+ channel protein type 8 subunit alpha; Na+ channel protein type VIII subunit alpha; voltage-gated Na+ channel subunit alpha Nav1.6 (SCN8A)

Function: - mediates voltage-dependent Na⁺ permeability of excitable membranes - assumes opened or closed conformation in response to voltage difference across membrane - forms a Na⁺-selective channel through which Na⁺ ions may pass in accordance with their electrochemical gradient - may be ubiquitinated by NEDD4L; which would promote its endocytosis (putative) - interacts with NEDD4 & NEDD4L (putative) Structure: - contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) & one positively charged segment (S4) - segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every 3rd position - belongs to the Na⁺ channel family - contains 1 IQ domain Compartment: membrane Alternative splicing: named isoforms=4

General

glycoprotein voltage-dependent Na+ channel protein alpha subunit

Properties

SIZE: entity length = 1980 aa MW = 225 kD COMPARTMENT: cellular membrane MOTIF: consensus repeat {114-442} MOTIF: transmembrane domain {128-151} transmembrane domain {160-179} transmembrane domain {193-211} N-glycosylation site {N215} transmembrane domain {218-237} transmembrane domain {253-277} N-glycosylation site {N289} N-glycosylation site {N295} N-glycosylation site {N308} N-glycosylation site {N326} transmembrane domain {388-413} N-glycosylation site {N544} N-glycosylation site {N640} consensus repeat {735-1007} MOTIF: transmembrane domain {748-772} transmembrane domain {784-807} transmembrane domain {816-835} transmembrane domain {842-862} N-glycosylation site {N877} transmembrane domain {878-898} ATP-binding site NAME: ATP-binding site SITE: 893-900 transmembrane domain {952-977} N-glycosylation site {N1047} N-glycosylation site {N1064} N-glycosylation site {N1091} consensus repeat {1180-1495} MOTIF: transmembrane domain {1194-1217} transmembrane domain {1231-1256} transmembrane domain {1263-1284} transmembrane domain {1289-1310} transmembrane domain {1330-1351} N-glycosylation site {N1358} N-glycosylation site {N1372} N-glycosylation site {N1383} transmembrane domain {1438-1464} consensus repeat {1504-1801} MOTIF: transmembrane domain {1518-1541} transmembrane domain {1553-1576} transmembrane domain {1583-1606} transmembrane domain {1617-1638} transmembrane domain {1654-1676} transmembrane domain {1742-1766} N-glycosylation site {N1768} IQ motif {1895-1924}

Database Correlations

OMIM 600702 UniProt Q9UQD0 PFAM correlations Entrez Gene 6334 Kegg hsa:6334

References

UniProt :accession Q9UQD0