Na+ channel protein type 6 subunit alpha; Na+ channel protein type 7 subunit alpha; voltage-gated Na+ channel subunit alpha Nax; Na+ channel protein cardiac & skeletal muscle subunit alpha (SCN7A, SCN6A)

Function: - mediates voltage-dependent Na⁺ permeability of excitable membranes - assumes opened or closed conformation in response to voltage difference across the membrane - forms a Na⁺-selective channel through which Na⁺ ions may pass in accordance with their electrochemical gradient Structure: - 24 transmembrane domains - contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) & one positively charged segment (S4) - segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every 3rd position - belongs to the Na⁺ channel family Compartment: membrane Expression: heart & uterus

General

glycoprotein voltage-dependent Na+ channel protein alpha subunit phosphoprotein

Properties

SIZE: entity length = 1682 aa MW = 193 kD COMPARTMENT: cellular membrane MOTIF: transmembrane domain {114-140} transmembrane domain {143-168} transmembrane domain {180-202} transmembrane domain {204-223} transmembrane domain {240-264} N-glycosylation site {N276} N-glycosylation site {N281} N-glycosylation site {N309} transmembrane domain {369-395} Ser phosphorylation site {S442} transmembrane domain {501-524} transmembrane domain {536-559} transmembrane domain {567-590} transmembrane domain {593-609} transmembrane domain {630-650} transmembrane domain {705-728} Thr phosphorylation site {T777} Ser phosphorylation site {S869} Ser phosphorylation site {S905} transmembrane domain {930-958} transmembrane domain {966-991} transmembrane domain {997-1019} transmembrane domain {1022-1040} transmembrane domain {1060-1080} N-glycosylation site {N1103} N-glycosylation site {N1113} transmembrane domain {1167-1193} transmembrane domain {1248-1270} transmembrane domain {1281-1305} transmembrane domain {1312-1335} transmembrane domain {1345-1369} transmembrane domain {1379-1405} transmembrane domain {1470-1496}

Database Correlations

OMIM 182392 UniProt Q01118 PFAM correlations Entrez Gene 6332 Kegg hsa:6332

References

UniProt :accession Q01118