Na+ channel protein type 3 subunit alpha; Na+ channel protein type III subunit alpha; voltage-gated Na+ channel subunit alpha Nav1.3; Na+ channel protein, brain III subunit alpha; voltage-gated Na+ channel subtype III (SCN3A, KIAA1356, NAC3)

Function: - mediates voltage-dependent Na⁺ permeability of excitable membranes - assumes opened or closed conformation in response to voltage difference across membrane - forms a Na⁺-selective channel through which Na⁺ ions may pass in accordance with their electrochemical gradient - may be ubiquitinated by NEDD4L; which would promote its endocytosis - the Na⁺ channel consists of a large polypeptide & 2-3 smaller ones - interacts with NEDD4L Structure: - large sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) & one positively charged segment (S4) - segment S4 is probably the voltage-sensors & is characterized by a series of positively charged amino acids at every 3rd position - belongs to the Na⁺ channel family - contains 1 IQ domain Compartment: membrane Alternative splicing: named isoforms=4

General

glycoprotein voltage-dependent Na+ channel protein alpha subunit transmembrane 24 protein

Properties

SIZE: entity length = 2000 aa MW = 226 kD COMPARTMENT: cellular membrane MOTIF: transmembrane domain {124-147} transmembrane domain {156-175} transmembrane domain {189-207} N-glycosylation site {N211} transmembrane domain {214-233} transmembrane domain {249-273} N-glycosylation site {N290} N-glycosylation site {N296} N-glycosylation site {N302} N-glycosylation site {N307} N-glycosylation site {N339} transmembrane domain {401-426} N-glycosylation site {N624} transmembrane domain {755-779} transmembrane domain {791-814} transmembrane domain {823-842} transmembrane domain {849-869} N-glycosylation site {N884} transmembrane domain {885-905} transmembrane domain {959-984} N-glycosylation site {N1051} N-glycosylation site {N1068} N-glycosylation site {N1134} transmembrane domain {1202-1225} transmembrane domain {1239-1264} transmembrane domain {1271-1292} transmembrane domain {1297-1318} transmembrane domain {1338-1359} N-glycosylation site {N1366} N-glycosylation site {N1380} transmembrane domain {1442-1468} transmembrane domain {1522-1545} transmembrane domain {1557-1580} transmembrane domain {1587-1610} transmembrane domain {1621-1642} transmembrane domain {1658-1680} transmembrane domain {1747-1771} IQ motif {1900-1929}

Database Correlations

OMIM 182391 UniProt Q9NY46 PFAM correlations Entrez Gene 6328

References

UniProt :accession Q9NY46