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Na+ channel protein type 11 subunit alpha; Na+ channel protein type XI subunit alpha; voltage-gated Na+ channel subunit alpha Nav1.9; sensory neuron Na+ channel 2; peripheral nerve Na+ channel 5; hNaN (SCN11A, PN5, SCN12A, SNS2)
Function:
- mediates voltage-dependent Na+ permeability of excitable membranes
- assumes opened or closed conformation in response to voltage difference across the membrane
- forms a Na+-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient
- tetrodotoxin-resistant Na+ channel isoform
- role in association with receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization
- voltage-resistant Na+ channel consists of an ion conducting pore forming alpha-subunit regulated by one or more auxiliary subunits SCN1B, SCN2B & SCN3B
Structure:
- contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) & one positively charged segment (S4)
- segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
- belongs to the Na+ channel family
Compartment: membrane
Alternative splicing: named isoforms=3
Expression:
- expressed in the dorsal root ganglia, trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine & placenta
Related
voltage-dependent Na+ channel
General
glycoprotein
voltage-dependent Na+ channel protein alpha subunit
phosphoprotein
transmembrane 24 protein
Properties
SIZE: entity length = 1791 aa
MW = 205 kD
COMPARTMENT: cellular membrane
MOTIF: consensus repeat {126-403}
MOTIF: transmembrane domain {127-148}
transmembrane domain {157-180}
transmembrane domain {193-212}
transmembrane domain {220-239}
transmembrane domain {256-269}
N-glycosylation site {N290}
N-glycosylation site {N338}
transmembrane domain {377-402}
consensus repeat {572-812}
MOTIF: transmembrane domain {573-596}
transmembrane domain {608-631}
transmembrane domain {640-659}
transmembrane domain {668-687}
transmembrane domain {703-725}
N-glycosylation site {N781}
transmembrane domain {786-811}
consensus repeat {1051-1309}
MOTIF: transmembrane domain {1052-1074}
transmembrane domain {1089-1114}
transmembrane domain {1121-1138}
transmembrane domain {1140-1161}
transmembrane domain {1181-1202}
N-glycosylation site {N1209}
N-glycosylation site {N1216}
N-glycosylation site {N1222}
N-glycosylation site {N1230}
Ser phosphorylation site {S1269}
transmembrane domain {1282-1308}
consensus repeat {1361-1605}
MOTIF: transmembrane domain {1362-1385}
transmembrane domain {1397-1420}
transmembrane domain {1427-1450}
transmembrane domain {1462-1484}
transmembrane domain {1500-1522}
N-glycosylation site {N1568}
transmembrane domain {1580-1604}
Database Correlations
OMIM 604385
UniProt Q9UI33
PFAM correlations
Entrez Gene 11280
Kegg hsa:11280
References
- UniProt :accession Q9UI33
- OMIM :accession 604385