SNW domain-containing protein 1; nuclear protein skiP; nuclear receptor coactivator NCoA-62; ski-interacting protein (SNW1, SKIIP, SKIP)

Function: 1) vitamin D-mediated transcription 2) splicing factor in pre-mRNA splicing 3) interacts with the ski oncogene 4) interacts with ATP1B4 (putative) 5) interacts with CHES1/FOXN3 6) identified in the spliceosome C complex Structure: belongs to the SNW family Compartment: - nucleus - found in spliceosomes (may also associate with non-spliceosomal proteins)

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 536 aa MW = 61 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl SNW {174-339} MOTIF: proline-rich region SITE: 219-233 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S224} Ser phosphorylation site {S232} Ser phosphorylation site {S234}

Database Correlations

OMIM 603055 UniProt Q13573 Pfam PF02731 Entrez Gene 22938 Kegg hsa:22938

References

UniProt :accession Q13573