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ski-like protein; ski-related protein; ski-related oncogene; sno-proto oncogene protein (SKIL, SNO)
Function:
- may have regulatory role in cell division or differentiation in response to extracellular signals
- interacts with SMAD2, SMAD3 & RNF111
- antagonizes TGF-beta signalling through direct interactions with SMAD2/SMAD4 & SMAD3/SMAD4
Structure:
- belongs to the SKI family
Alternative splicing:
- named isoforms=4; SNON, SNOA, SNON2, SNOI
Expression:
- SNON & SNOA isoforms are widely expressed
- highest expression is found in skeletal muscle, followed by placenta & lung
- lowest expression in heart, brain & pancreas
- expression of isoform SNOI is restricted to skeletal muscle
Interactions
molecular events
General
phosphoprotein
proto oncogene protein
transcription factor (TF)
Properties
SIZE: entity length = 684 aa
MW = 77 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S26}
coiled coil {536-684}
References
UniProt :accession P12757
Component-of
molecular complex
Databases & Figures
OMIM 165340
UniProt P12757
PFAM correlations
Entrez Gene 6498
Kegg hsa:6498
TGF-beta/BMP signaling