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SNF-related serine/threonine protein kinase; SNF1-related kinase (SNRK, KIAA0096, SNFRK)
Function: (postulated)
1) hematopoietic cell proliferation/differentiation
2) neuronal apoptosis
3) activated by phosphorylation on Thr-173 by STK11/LKB1 in complex with STRADA pseudo kinase & CAB39
4) autophosphorylated
Cofactor: Mg+2
Structure:
- belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family
- contains 1 protein kinase domain
- contains 1 UBA domain
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression:
- expressed in hematopoietic progenitor cells, leukemic cell lines > testis
General
nuclear protein
serine/threonine kinase
Properties
SIZE: entity length = 765 aa
MW = 84 kD
COMPARTMENT: cell nucleus
MOTIF: kinase domain
SITE: 16-269
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 22-30
ATP-binding site
NAME: ATP-binding site
SITE: 45-45
aspartate residue {D139}
Thr phosphorylation site {T173}
UBA domain {291-334}
Ser phosphorylation site {S390}
Ser phosphorylation site {S569}
Ser phosphorylation site {S607}
STATE: active state
Database Correlations
OMIM 612760
UniProt Q9NRH2
Pfam PF00069
Entrez Gene 54861
Kegg hsa:54861
ENZYME 2.7.11.1
References
UniProt :accession Q9NRH2