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SNARE [soluble NSF attachment receptor] protein (SNARE, SNAP receptor)

Function: 1) mediate fusion of cellular transport vesicles with a target compartment a) lysosome b) docking of synaptic vesicles with presynaptic membrane 2) metastable 'trans' complexes are formed from 3 SNAREs: a) syntaxin 1 (plasma membrane) b) SNAP-25 (plasma membrane) c) synaptobrevin (vesicular) Compartment: - plasma membrane, vesicles - vesicular, v-SNAREs, found in transport vesicles during budding - target, t-SNAREs, found membranes of target compartments Pathology: - SNAREs are targets of the bacterial neurotoxins responsible for botulism & tetanus Comparative biology: - a large protein superfamily, > 60 members in yeast & mammals

Specific

Golgi SNAP receptor complex member 1; 28 kD Golgi SNARE protein; 28 kD cis-Golgi SNARE p28; GOS-28 (GOSR1, GS28) Golgi SNAP receptor complex member 2; 27 kD Golgi SNARE protein; membrin (GOSR,2 GS27) synaptobrevin homolog YKT6 synaptobrevin or vesicle-associated membrane protein (VAMP) synaptosomal-associated protein 25; SNAP-25; synaptosomal-associated 25 kD protein; super protein; SUP (SNAP25 SNAP) syntaxin vesicle transport protein SEC20 (BCL2/adenovirus E1B 19 kD protein-interacting protein 1, transformation-related gene 8 protein, TRG-8, BNIP1, NIP1, SEC20L, TRG8) vesicle transport protein USE1; USE1-like protein; MAPK-activating protein PM26; protein p31 (USE1L, USE1) vesicle transport through interaction with t-SNAREs homolog 1A (vesicle transport v-SNARE protein Vti1-like 2, Vti1-rp2, VTI1A) vesicle transport through interaction with t-SNAREs homolog 1B (vesicle transport v-SNARE protein Vti1-like 1, Vti1-rp1, VTI1B, VTI1, VTI1L, VTI1L1, VTI2) vesicle-associated membrane protein 4 (VAMP-4, VAMP4) vesicle-associated membrane protein 5 (VAMP-5, myobrevin, VAMP5) vesicle-associated membrane protein 8 (VAMP-8, endobrevin, EDB, VAMP8) vesicle-trafficking protein SEC22b; SEC22 vesicle-trafficking protein homolog B; SEC22 vesicle-trafficking protein-like 1 (ERS24, ERS-24, SEC22B, SEC22L1)

General

membrane protein receptor

Properties

COMPARTMENT: intracellular vesicle MOTIF: ligand-binding site membrane region SNARE motif

References

  1. http://en.wikipedia.org
  2. Karp, Gerald, Cell and Molecular Biology 4th Edition, John Wiley & Sons, 2002
  3. Sztul E, Lupashin V. Role of tethering factors in secretory membrane traffic. Am J Physiol Cell Physiol. 2006 Jan;290(1):C11-26. Review. PMID: 16338975
  4. Duman JG, Forte JG. What is the role of SNARE proteins in membrane fusion? Am J Physiol Cell Physiol. 2003 Aug;285(2):C237-49. Review. PMID: 12842832