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small nuclear RNA-activating protein complex (SNAPc)
Function:
- required for transcription of both RNA polymerase 1 & RNA polymerase 3 transcribed small-nuclear RNA genes
- SNAPc binds to the proximal sequence element (PSE) of snRNA promoters
Structure:
- composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 & SNAPC5
Related
snRNA-activating protein complex (GO:0019185)
General
general transcription factor (basal transcription factor, transcription initiation factor)
molecular complex
Properties
COMPARTMENT: cell nucleus
SUBUNITS: small nuclear RNA-activating protein-43
MOTIF: binding site
SITE: 1-168
FOR-BINDING-OF: small nuclear RNA-activating protein-50
binding site
SITE: 164-268
glutamate residue {347-352} (6)
small nuclear RNA-activating protein-45
small nuclear RNA-activating protein-50
MOTIF: Ser phosphorylation site {S74}
small nuclear RNA-activating protein-19
MOTIF: glutamate residue {86-95} (10)
small nuclear RNA-activating protein-190
MOTIF: binding site
SITE: 84-133
FOR-BINDING-OF: small nuclear RNA-activating protein-19
DNA-binding motif
SITE: 238-288
DNA-binding motif
SITE: 289-341
DNA-binding motif
SITE: 341-395
DNA-binding motif
SITE: 396-447
DNA-binding motif
SITE: 448-499
proline-rich region
SITE: 931-1264
MOTIF: proline residue (SEVERAL)
Thr phosphorylation site {T1157}
Ser phosphorylation site {S1224}
binding site
SITE: 1281-1393
FOR-BINDING-OF: small nuclear RNA-activating protein-45
References
- Henry RW, Sadowski CL, Kobayashi R, Hernandez N.
A TBP-TAF complex required for transcription of human snRNA
genes by RNA polymerase II and III.
Nature. 1995 Apr 13;374(6523):653-6.
PMID: 7715707
Components
small nuclear RNA-activating protein-190; small nuclear RNA-activating protein complex polypeptide 4; PSE-binding trasnscription factor alpha; snRNA-activating protein complex subunit 4; SNAPc subunit 4; snRNA-activating protein complex 190 kD subunit; SNAPc 190 kD subunit,; proximal sequence element-binding transcription factor alpha subunit; PTF alpha subunit (SNAP190, SNAPC4)
small nuclear RNA-activating protein-19; small nuclear RNA-activating protein complex polypeptide 5 (SNAP19, SNAPC5)
small nuclear RNA-activating protein-43; SNAPc 43 kDa subunit; proximal sequence element-binding transcription factor gamma subunit; PSE-binding factor gamma subunit; PTF gamma subunit (SNAP43, SNAPC1)
small nuclear RNA-activating protein-45; SNAPc 45 kDa subunit; proximal sequence element-binding transcription factor delta subunit; PSE-binding factor delta subunit; PTF delta subunit (SNAP45)
small nuclear RNA-activating protein-50; SNAPc 50 kDa subunit; proximal sequence element-binding transcription factor beta subunit; PSE-binding factor beta subunit; PTF beta subunit (SNAP50, SNAPC3)