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small nuclear RNA-activating protein-50; SNAPc 50 kDa subunit; proximal sequence element-binding transcription factor beta subunit; PSE-binding factor beta subunit; PTF beta subunit (SNAP50, SNAPC3)
Function:
- part of the SNAPc complex
- binds to proximal sequence element (PSE), a non-TATA-box basal
- recruits TBP & BRF2 to the U6 snRNA TATA box
- phosphorylated upon DNA damage, probably by ATM or ATR
Compartment: nucleus
General
nuclear protein
phosphoprotein
protein subunit
Properties
SIZE: entity length = 411 aa
MW = 47 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S74}
MISC-INFO: pI 4.9
Database Correlations
OMIM 602348
UniProt Q92966
Entrez Gene 6619
Kegg hsa:6619
References
- Henry RW, Sadowski CL, Kobayashi R, Hernandez N.
A TBP-TAF complex required for transcription of human snRNA
genes by RNA polymerase II and III.
Nature. 1995 Apr 13;374(6523):653-6.
PMID: 7715707
- UniProt :accession Q92966
- OMIM :accession 602348
Component-of
small nuclear RNA-activating protein complex (SNAPc)