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zinc finger protein SNAI2; protein snail homolog 2; neural crest transcription factor Slug (SNAI2, SLUG, SLUGH)
Function:
- transcriptional repressor
- role in generation & migration of neural crest cells
Structure:
- belongs to the snail C2H2-type Zn+2-finger protein family
- contains 5 C2H2-type Zn+2 fingers
Compartment: nucleus (probable)
Expression:
- expressed in placenta & adult heart, pancreas, liver, kidney & skeletal muscle
Pathology:
- defects in SNAI2 are a cause of neural tube defects
- defects in SNAI2 are the cause of Waardenburg syndrome type 2D
General
C2H2 type zinc finger protein
snail protein homolog
Properties
SIZE: entity length = 268 aa
MW = 30 kD
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 128-150
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 159-181
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 185-207
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 213-235
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 241-264
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM correlations
UniProt O43623
Pfam PF00096
Entrez Gene 6591
Kegg hsa:6591
References
- UniProt :accession O43623
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/SNAI2ID453.html
- Entrez Gene :accession 6591