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Sn1-specific diacylglycerol lipase alpha (DGL-alpha, neural stem cell-derived dendrite regulator, DAGLA, C11orf11, KIAA0659, NSDDR)
Function:
- catalyzes hydrolysis of diacylglycerol to 2-arachidonoyl-glycerol
- required for axonal growth during development & for retrograde synaptic signaling at mature synapses
Cofactor: Ca+2
Inhibition:
- inhibited by p-hydroxy-mercuri-benzoate, HgCl2, RHC80267
Kinetic parameters:
- KM=154.7 uM for diacylglycerol
- Vmax=33.3 nmol/min/mg enzyme
- Optimum pH is 7.0 Strucuture:
- highly expressed in brain & pancreas
- belongs to the AB hydrolase superfamily, Lipase family
Compartment: cell membrane
General
glycoprotein
hydrolase
phosphoprotein
transmembrane 4 protein
Properties
SIZE: MW = 115 kD
entity length = 1042 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-22}
transmembrane domain {23-43}
exoplasmic loop {44-60}
transmembrane domain {61-81}
cytoplasmic loop {82-101}
transmembrane domain {102-122}
exoplasmic loop {123-136}
MOTIF: N-glycosylation site {N133}
transmembrane domain {137-157}
cytoplasmic domain {158-1042}
MOTIF: serine residue {S472}
aspartate residue {D524}
Ser phosphorylation site {S727}
Ser phosphorylation site {S732}
Database Correlations
UniProt Q9Y4D2
Pfam PF01764
References
UniProt :accession Q9Y4D2