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cysteine & glycine-rich protein 2; LIM domain only protein 5; LMO-5; smooth muscle cell LIM protein; SmLIM (CSRP2, LMO5, SMLIM)
Function:
- drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation & dedifferentiation
- seems to play a role in the development of the embryonic vascular system
- interacts with CSRP2BP; the LIM domain 1 is necessary & sufficient for this interaction
- interacts with GLRX3
Structure:
- contains 2 LIM Zn+2-binding domains
Compartment:
- nucleus (putative)
Expression:
- highly expressed in the aorta
- lesser if any expression in heart & skeletal muscle
Related
Cysteine-rich protein 2; CRP-2; protein ESP1 (CRIP2, CRP2)
General
LIM domain protein
nuclear protein
Properties
SIZE: entity length = 193 aa
MW = 21 kD
COMPARTMENT: cell nucleus
MOTIF: LIM domain {10-61}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
glycine-rich region {63-78}
MOTIF: nuclear translocation signal {64-69}
LIM domain {119-170}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
glycine-rich region {176-187}
Database Correlations
OMIM 601871
UniProt Q16527
Pfam PF00412
Entrez Gene 1466
Kegg hsa:1466
References
UniProt :accession Q16527