smoothelin (SMTN SMSMO)

Function: - structural protein of the cytoskeleton - isoforms L1 & L2 phosphorylated on Thr-373 Structure: - belongs to the smoothelin family - contains 1 CH (calponin-homology) domain Compartment: - cytoplasm, cytoskeleton - exhibits a filamentous organization Alternative splicing: - named isoforms=6' A, B, B2, B3, L1, L2 - additional isoforms seem to exist Expression: - expressed in smooth muscle; contractile or vascular

General

cytoskeletal protein phosphoprotein

Properties

SIZE: entity length = 917 aa MW = 100 kD COMPARTMENT: cytoplasm MOTIF: coiled coil {24-89} proline-rich region SITE: 194-282 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S245} Ser phosphorylation site {S301} Ser phosphorylation site {S304} Ser phosphorylation site {S341} Thr phosphorylation site {T351} Ser phosphorylation site {S357} Thr phosphorylation site {T360} Ser phosphorylation site {S503} Ser phosphorylation site {S514} Ser phosphorylation site {S576} coiled coil {603-630} serine-rich region {710-715} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S729} calponin homology domain NAME: calponin homology domain SITE: 799-903

Database Correlations

OMIM 602127 UniProt P53814 PFAM correlations Entrez Gene 6525 Kegg hsa:6525